Method for removing pertussis endoxin, pertussis toxoid and...

Details Method for removing pertussis endoxin, pertussis toxoid and... Method for removing pertussis endoxin, pertussis toxoid and...

A - Human Necessities

61

K

167/135, 530/15.

A61K 39/10 (2006.01) C07K 15/04 (1990.01)

Patent

CA 1326444

ABSTRACT OF THE DISCLOSURE The present invention provides a clear and efficient pertussis endotoxin-removing method characterized in that a fluid containing the antiinfective fraction and endotoxin of strains of phase I Bordetella pertussis is supplied with calcium ion in the presence of excess phosphate ion prior to zonal centrifugation and also a pertussis toxoid whose endotoxin content per 10 µg of proteinic nitrogen is not more than 0.5 ng and its production method.

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