C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) C12Q 1/02 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2128399
- 107 - Abstract of the disclosure: There is disclosed a method for evaluation of the safety of a chemical compound, which includes the steps of: (a) reacting a chemical compound with recombinant yeast cells expressing, or in other words producing, human cytochrome P450 molecular species P450 1A2, P450 2C9, P450 2E1 and P450 3A4 together with a yeast NADPH-P450 reductase, which may be in the form of a fused enzyme with each of said human cytochrome P450 molecular species, or with the cell free extracts of the yeast cells; and (b) analyzing the resulting metabolite to determine the safety of the compound. According to this method, it can be determined whether a test compound will be converted into a carcinogenic or mutagenic form through the metabolism in the human liver, and whether the test compound or its metabolite has mutagenicity.
Hayashi Koji
Kaneko Hideo
Komai Koichiro
Nakatsuka Iwao
Sakaki Toshiyuki
Kirby Eades Gale Baker
Sumitomo Chemical Co. Ltd.
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