Method for screening agents capable of treating obesity

Details Method for screening agents capable of treating obesity Method for screening agents capable of treating obesity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61P 3/04 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2428492

The invention concerns a method for screening agents capable of treating, by way of prevention or cure, obesity or one of the disorders associated with obesity by modulating the expression of the SPARC protein or of its activity. The invention also concerns a method for diagnosing obesity or one of the disorders associated with obesity by monitoring the expression rate of the SPARC protein or its activity. The invention further concerns a composition comprising an agent modulating the expression of the SPARC protein or its activity. The invention finally concerns the use of any agent modulating the expression of the SPARC protein or its activity for preparing a pharmaceutical composition for treating, by way of prevention or cure, obesity or one of the disorders associated with obesity.

La présente invention a pour objet une méthode de criblage d'agents susceptibles de traiter, de manières préventive ou curative, l'obésité ou l'un des désordres associés à l'obésité par modulation de l'expression de la protéine SPARC ou de son activité. Elle a également trait é une méthode de diagnostic de l'obésité ou de l'un désordres associés à l'obésité en suivant le taux d'expression de la proteine SPARC ou de son activité. Elle concerne une composition comprenant au moins un agent modulant l'expression de la protéine SPARC ou son activité. Elle concerne aussi l'utilisation de tout agent modulant l'expression de la protéine SPARC ou son activité pour la préparation d'une composition pharmaceutique destinée à traiter, de manière préventive ou curative, l'obésité ou l'un des désordres associés à l'obésité.

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