C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 45/00 (2006.01) A61P 3/08 (2006.01) C07K 14/47 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2491417
It is intended to disclose a method of identifying a novel substance, which promotes the interaction between PPAR.gamma. and RNA helicase and/or accelerates the expression of p68 RNA helicase to thereby promote the transcriptional induction activity of PPAR.gamma. and improve insulin resistance, and a method of screening the same. The above method is a method of screening an insulin resistance improving drug of a novel type which is different from the existing PPAR agonists promoting the transcriptional induction activity of PPAR.gamma.. It is also intended to disclose a process for producing a medicinal composition for improving insulin resistance containing, as the active ingredient, a substance which can be obtained by the above screening method.
L'invention concerne un procédé d'identification de substance favorisant l'interaction entre PPAR.gamma. et une hélicase d'ARN et/ou accélérant l'expression de l'hélicase d'ARN p68 afin de favoriser l'activité d'induction transcriptionnelle de PPAR.gamma. et d'améliorer la sensibilité à l'insuline, ainsi qu'un procédé de criblage de cette substance. Le procédé ci-dessus est un procédé de criblage d'un médicament, améliorant la sensibilité à l'insuline, d'un type nouveau, différent des agonistes de PPAR existants, favorisant l'activité d'induction transcriptionnelle de PPAR.gamma.. L'invention concerne aussi un processus de production d'une composition médicinale, destinée à améliorer la sensibilité à l'insuline, contenant, en tant que principe actif, une substance pouvant être obtenue au moyen du précédent procédé de criblage.
Endoh Hideki
Ogino Makoto
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
LandOfFree
Method for screening an agent for improving insulin resistance does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for screening an agent for improving insulin resistance, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for screening an agent for improving insulin resistance will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2038777