A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01)
Patent
CA 2671987
The present invention relates to a method for screening an anticancer compound and an anticancer compound screened using the method, and more particularly, to a method for screening an anticancer compound, the method comprising: culturing cancer cells expressing the oncogenic protein transmembrane 4 L6 family member 5 (TM4SF5), expressed as the polypeptide of SEQ ID NO: 2, treating the cancer cells with an anticancer candidate, and determining that the anticancer candidate is an anticancer substance when the candidate exhibits antagonistic activity against tumor formation and metastasis based on several events through the molecular mechanism of TM4SF5. The present invention also relates to chalcone compounds screened to have anticancer activity using the method, and an anticancer composition comprising the compound as an effective ingredient.
L'invention concerne un procédé pour le criblage d'un composé anticancéreux, ainsi qu'un composé anticancéreux criblé selon ce procédé. L'invention concerne notamment un procédé pour le criblage d'un composé anticancéreux qui consiste à cultiver des cellules cancéreuses exprimant le membre 5 oncogène de la famille des protéines transmembranaires 4 L6 (TM4SF5), exprimé en tant que polypeptide de SEQ ID NO: 2, à traiter les cellules cancéreuses à l'aide d'un candidat anticancéreux et à déterminer que le candidat anticancéreux est une substance anticancéreuse lorsque le candidat fait preuve d'une activité antagoniste envers la formation de tumeurs et les métastases sur la base de plusieurs événements via le mécanisme moléculaire de TM4SF5. L'invention concerne également des composés chalcone criblés comme ayant une activité anticancéreuse selon le procédé de l'invention, ainsi qu'une composition anticancéreuse comprenant le composé en tant que principe actif.
Lee Jung Weon
Lee Sin-Ae
Park Ki Hun
Ryu Hyung Won
Ryu Young Bae
Benoit & Cote Associes Inc.
Industry-Academic Cooperation Foundation Gyeongsang National Uni
Seoul National University Industry Foundation
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