Method for screening cd14 agonist or antagonist

Details Method for screening cd14 agonist or antagonist Method for screening cd14 agonist or antagonist

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 45/00 (2006.01) A61P 31/00 (2006.01) A61P 37/04 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2351065

A compound capable of changing the binding properties of a lipopolysaccharide to a membrane-bound protein CD14 can be efficiently screened by using a labeled lipoprotein and cells with the expression of CD14.

L'invention concerne un procédé de criblage d'un composé capable de modifier les propriétés de liaison d'un lipopolysaccharide à une protéine CD14 membranaire, ce procédé s'appuyant notamment sur l'utilisation d'une lipoprotéine marquée et de cellules exprimant ladite protéine CD14.

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