G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/569 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2452663
The invention relates to a method for screening molecules which can bind to the gp 120 protein of the immunodeficiency virus. The inventive method uses the fluorescene anisotropy technique and the peptide of the following formula (I): TPA- Xaaa- Xaab- Ala or Gln or His - Arg ou Phe - Cys - Xaac- Xaad- Arg - Cys - Lys - Xaae- Xaaf- Xaag- Xaah- Leu ou Lys - Xaai - Lys - Cys - Ala or Gln - Gly or (D)Asp or Ser - Ser or His or Asn - Xaaj- Cys - Thr or Ala - Cys - Xaak-NH2, (I) wherein TPA represents thiopropionic acid, Xaaa, Xaab, Xaac, Xaad, Xaae, Xaaf, Xaag, Xaah, and Xaai are naturals or non natural amino acids which are identical or different, Xaaj represents b-naphtylalanine or phenylalanine or bi-phenylalanine, and Xaak represents Gly or Val or Ile.
La présente invention se rapporte à un procédé de criblage de molécules aptes à se lier à la protéine gp120 du virus de l'immunodéficience.Le procédé de la présente invention utilise la technique d'anisotropie de fluorescence et le peptide de formule (I) suivante : TPA- Xaaa- Xaab- Ala ou Gln ou His - Arg ou Phe - Cys - Xaac- Xaad- Arg - Cys - Lys - Xaae- Xaaf- Xaag- Xaah- Leu ou Lys - Xaai - Lys - Cys - Ala ou Gln - Gly ou (D)Asp ou Ser - Ser ou His ou Asn - Xaaj- Cys - Thr ou Ala - Cys - Xaak-NH2, (I) dans laquelle TPA représente l'acide thiopropionique, Xaaa, Xaab, Xaac, Xaad, Xaae, Xaaf, Xaag, Xaah, et Xaai, sont des acides aminés, naturels ou non naturels, identiques ou différents, Xaaj représente la b-naphtylalanine ou la phénylalanine ou la bi-phénylalanine, et Xaak représente Gly ou Val ou Ile.
Pogenberg Vivian
Royer Catherine
Vita Claudio
Commissariat A. L'energie Atomique
Goudreau Gage Dubuc
Institut National de La Sante Et de La Recherche Medicale
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