Method for searching for peptides and process for producing...

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G01N 33/68 (2006.01) C07K 1/04 (2006.01) C07K 14/81 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2262116

Peptides having enhanced physiological activities are screened via the step (a) of synthesizing an arbitrary number of peptides having arbitrary amino acid sequences different from each other, the step (b) of measuring the desired physiological activities of the peptides synthesized in the step (a) and thus screening an arbitrary number of amino acids having high physiological activities, the step (c) of synthesizing peptides having amino acid sequences which are obtained by processing the data of the amino acid sequences and physiological activities of the peptides screened in the step (c) by a genetic algorithm, and the step (d) of subjecting the peptides obtained in the step (c) to the steps (b) and (c) repeatedly an arbitrary number of times. In the genetic algorithm, each amino acid is expressed in a definite indication and the amino acid sequences of the peptides thus indicated are employed as genes.

On recherche par criblage des peptides possédant une efficacité physiologique améliorée par l'intermédiaire d'étapes (a) de synthèse d'un nombre arbitraire de peptides possédant des séquences aminoacides arbitraires différentes les unes des autres; (b) de mesure de l'efficacité physiologique souhaitée des peptides synthétisés à l'étape (a) et, par conséquent, de recherche d'un nombre arbitraire d'acides aminés possédant une efficacité physiologique élevée; (c) de synthèse des peptides possédant des séquences aminoacides obtenues par traitement des données des séquences aminoacides et de l'efficacité physiologique des peptides soumis à un criblage à l'étape (c) au moyen d'un algorithme génétique; (d) de soumission des peptides obtenus à l'étape (c) aux étapes (b) et (c) de façon répétée un nombre arbitraire de fois. Dans l'algorithme génétique, chaque acide aminé est exprimé de façon définie et les séquences aminoacides des peptides ainsi définies sont utilisées en tant que gènes.

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