Method for selecting a candidate drug compound

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 17/02 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C40B 30/04 (2006.01) C40B 50/18 (2006.01) G01N 33/68 (2006.01) C40B 40/10 (2006.01)

Patent

CA 2517834

The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, said method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule capable of reacting with said at least first and second reactive group; contacting said scaffold with said at least one molecule to form at least two linkages between said scaffold and said at least one molecule in a coupling reaction, whereby the formation of a linkage accelerates the formation of a consecutive linkage, preferably wherein said coupling reaction is performed in solution, more preferably in an aqueous solution. Furthermore, a method is provided for selecting a candidate drug compound, comprising providing a library of compounds according to the invention and determining the binding of a target molecule to said compounds.

L~invention concerne le domaine des essais réalisés sur des médicaments d~intérêt potentiel et celui de la mis au point des médicaments. Elle décrit un procédé pour créer un composé constitué d~au moins une molécule fixée à un squelette moléculaire par l~intermédiaire deux liaisons, ledit procédé consistant à prendre un squelette comportant au moins un premier et un deuxième groupe réactifs ; à prendre au moins une molécule capable de réagir avec lesdits au moins premier et deuxième groupe réactifs ; à mettre en contact ledit squelette avec ladite au moins une molécule pour former au moins deux liaisons entre ledit squelette et ladite molécule lors d~une réaction de couplage, la formation d~une liaison accélérant ainsi la formation d~une liaison consécutive, ladite réaction de couplage s~effectuant de préférence en solution, et mieux encore dans une solution aqueuse. Par ailleurs, l~invention décrit un procédé pour sélectionner un composé médicamenteux d~intérêt potentiel, consistant à créer une banque de composés selon l~invention et à déterminer la fixation d~une molécule cible sur lesdits composés.

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