Method for selective opening of abnormal brain tissue...

Details Method for selective opening of abnormal brain tissue... Method for selective opening of abnormal brain tissue...

A - Human Necessities

61

K

A61K 38/22 (2006.01) A61K 38/04 (2006.01) A61M 5/00 (2006.01)

Patent

CA 2162055

A method for selectively opening abnor- mal brain tissue capillaries of a mammal in order to allow selective passage of both low and high molecular weight neuropharmaceutical agents into abnormal brain tissue. The method utilizes direct infusion of bradykinin into the carotid artery. The dose of bradykinin is main- tained at levels which provide opening of ab- normal brain tissue capillaries without opening normal brain capillaries. The method is useful for introducing a wide variety of neuropharma- ceutical agents selectively to brain tumors and other abnormal brain tissue.

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