Method for selective reduction of aromatic compounds

C - Chemistry – Metallurgy – 07 – B

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C07B 35/02 (2006.01) C07B 35/04 (2006.01)

Patent

CA 2552438

A method for the selective reduction of an aromatic compound. The present invention provides a method for preventing the reduction of at least one halogen substituted aromatic ring of an aromatic compound, while allowing the reduction of at least one functional group on the aromatic compound. In the present invention at least one hydroxyl group is placed on the at least one halogen substituted aromatic ring to be protected from reduction. The aromatic compound is then reacted with at least one alkali metal in at least one nitrogen containing base and at least one alcohol at a ratio of the alcohol to the nitrogen containing base at which the aromatic ring with the hydroxyl group is protected from reduction, while the desired functional group is reduced.

La présente invention concerne un procédé de réduction sélective d'un composé aromatique. Ce procédé permet d'empêcher la réduction d'au moins un noyau aromatique à substitution halogène d'un composé aromatique, tout en permettant la réduction d'au moins un groupe fonctionnel sur ce composé aromatique. Selon la présente invention, au moins un groupe hydroxyle est placé sur ledit noyau aromatique à substitution halogène qui doit être protégé de la réduction. Le composé aromatique est ensuite mis en réaction avec au moins un métal alcalin dans au moins une base contenant de l'azote et dans au moins un alcool, avec un rapport de l'alcool sur la base contenant de l'azote auquel le noyau aromatique avec le groupe hydroxyle est protégé d'une réduction, alors que le groupe fonctionnel souhaité est réduit.

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