Method for selectively binding a substrate to sorbents by...

G - Physics – 01 – N

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G01N 33/543 (2006.01) B01J 19/00 (2006.01) B01J 20/32 (2006.01)

Patent

CA 2519479

The invention relates to a method for selectively binding to at least one sorbent a substrate having at least two different groups capable of binding. The inventive method is characterized by comprising steps (i) to (iv): (i) determining at least two groups capable of binding a sorbent from a synthetic or natural first substrate, (ii) applying at least two different groups that are capable of binding a second synthetic or natural substrate to one carrier each, thereby forming at least one sorbent, whereby the groups are the same groups of step (i) or groups that are complementary or non-complementary thereto, and the second substrate of step (ii) is the same or different from the first substrate according to step (i), (iii) contacting at least one second substrate that may be the same or different from the first substrate with at least one sorbent of step (ii), (iv) testing the binding strength of the at least one second substrate to the at least one sorbent of step (iii), while using at least one sorbent whose production comprises steps (i) to (ii). The invention also relates to a combinatorial library which comprises a collection of sorbents having at least two different groups each.

Procédé de liaison sélective d'un substrat possédant au moins deux groupes différents rendus capables de liaison avec au moins un sorbant, qui consiste (i) à déterminer au moins deux groupes rendus capables de liaison avec un sorbant à partir d'un premier substrat synthétique ou naturel, (ii) à déposer au moins deux groupes différents rendus capables de liaison avec un deuxième substrat synthétique ou naturel sur un support, avec formation d'au moins un sorbant, ces groupes étant identiques aux groupes de l'étape (i), ou des groupes complémentaires ou non complémentaires de ceux de l'étape (i), et le deuxième substrat de l'étape (ii) étant identique au premier substrat de l'étape (i) ou différent de ce dernier, (iii) à mettre en contact au moins un deuxième substrat, qui peut être identique au premier substrat ou différent de ce dernier, avec au moins un sorbant de l'étape (ii), et (iv) à vérifier la force de liaison du deuxième substrat au moins au sorbant de l'étape (iii), au moins un sorbant étant utilisé, dont la préparation comprend les étapes (i) et (ii).

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