G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 27/447 (2006.01) C07K 1/26 (2006.01) C07K 14/76 (2006.01)
Patent
CA 2403190
The invention relates to a method for capillary electrophoresis in free solution with alkaline an pH, for analysing biological samples comprising protein constituents. Said method is characterised in that it comprises at least one step whereby the sample is introduced into a capillary tube containing an analysis buffer. Said analysis buffer also comprises at least one additive capable of hydrophobic interaction with one or more protein constituents and capable of providing said protein constituent(s) with one or more negative charges and of altering the electrophoretic mobility thereof. The invention also relates to analysis buffer compositions for carrying out said method.
L'invention concerne un procédé d'électrophorèse capillaire en solution libre à pH alcalin pour l'analyse d'échan- tillons biologiques comportant des constituants protéiques, caractérisé en ce qu'il comporte au moins une étape où on introduit l'échantillon dans un tube capillaire contenant un tampon d'analyse, ledit tampon d'analyse comportant en outre au moins additif capable d'intercation hydrophobe avec un ou plusieurs constituants protéiques et capable d'apporter à ce ou ces constituants pro- téiques une ou plusieurs charges négatives et d'en modifier la mobilité électrophorétique. Elle concerne également des compositions de tampon d'analyse pour sa mise en oeuvre.
Nouadje Georges
Robert Frederic
Fetherstonhaugh & Co.
Sebia
LandOfFree
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