C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/02 (2006.01) B01D 15/32 (2006.01)
Patent
CA 2585533
A process for the purification of an impure preparation containing hydrocodone by means of a reverse phase preparative chromatography process is provided. In an illustrative embodiment a chromatographic column is loaded with a stationary phase, typically a silica particle having an organic ligand bound thereto. The impure preparation is acidified and passed through the column with a loading ratio of from about 10 to about 1000. The column is eluted, typically with an aqueous solution of acetonitrile, and the purified hydrocodone is obtained in a specified fraction.
La présente invention a pour objet un procédé de purification d~un mélange contenant de l~hydrocodone par chromatographie préparative en phase inverse. Dans un mode de l~invention pouvant servir d~exemple de référence, une colonne chromatographique est chargée avec une phase stationnaire, typiquement des particules de silice liées à un ligand organique. Le mélange contenant l~hydrocodone est acidifié et passé à travers la colonne, dont la masse de la charge de silice est comprise entre 10 et 1 000 fois celle du mélange. La colonne est éluée, typiquement à l'aide d'une solution aqueuse d'acétonitrile, et l'hydrocodone purifiée est obtenue dans une fraction déterminée.
Mallinckrodt Inc.
Osler Hoskin & Harcourt Llp
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