A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 31/203 (2006.01)
Patent
CA 2405471
The invention concerns a method for stabilising particle size distribution of a powdery active principle, when the latter is dispersed in a liquid. Said method is characterised in that it consists in dispersing said active principle in a glycol ether or a mixture of glycol ethers. The invention also concerns the uses of said method and, in particular for pharmaceutical compositions and galenic forms comprising a retinoid as active principle, and suited for providing the latter with improved bioavailability ( suprabioavailability ) after oral administration.
La présente invention se rapporte à un procédé pour stabiliser la granulométrie d'un principe actif pulvérulent, lorsque celui-ci est dispersé dans un liquide, caractérisé en ce qu'il consiste à disperser ce principe actif dans un éther de glycol ou un mélange d'éthers de glycol. La présente invention se rapporte également aux applications de ce procédé et, notamment, à des compositions pharmaceutiques et des formes galéniques comprenant un rétinoïde en tant que principe actif, et aptes à conférer à ce dernier une biodisponibilité améliorée ("suprabiodisponibilité") après une administration orale.
Gimet Rene
Laruelle Claude
Toselli Dominique
Borden Ladner Gervais Llp
Cll Pharma
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