Method for stabilization of peptides in a biological sample

G - Physics – 01 – N

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G01N 33/68 (2006.01) C07K 9/00 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01)

Patent

CA 2614592

A convenient method of stabilizing peptides contained in a biosample, and a relevant stabilizing reagent; a convenient method of preserving a biosample containing peptides, and a relevant preserving reagent; and an accurate method of measuring peptides contained in a biosample, and a relevant measuring reagent. By adding a member of sugars to a biosample, there can be attained stabilization of peptides contained in the biosample, preserving of a biosample containing peptides with the peptides held in stabilized form, and accurate measuring of peptides contained in the biosample. Accordingly, as peptides contained in a biosample taken in clinical test can be stabilized, in clinical test, there can be accurately measured peptides being markers of the biosample.

L'invention concerne un procédé facile de stabilisation de peptides contenus dans un échantillon biologique et un réactif stabilisateur adéquat ; un procédé commode pour conserver un échantillon biologique qui contient des peptides et un agent conservateur adéquat ; un procédé exact pour mesurer les peptides contenus dans un échantillon biologique et un réactif de mesure adéquat. En ajoutant un membre des sucres à un échantillon biologique, on peut obtenir une stabilisation des peptides contenus dans l'échantillon biologique, préserver un échantillon biologique contenant des peptides, les peptides étant contenus sous forme stabilisée, et mesurer exactement les peptides contenus dans l'échantillon biologique. Par conséquent, comme les peptides contenus dans un échantillon biologique prélevé pour test clinique peuvent être stabilisés, dans le test clinique, les peptides mesurés précisément peuvent servir de marqueurs dans l'échantillon biologique.

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