A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/36 (2006.01) A61K 38/37 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61L 2/00 (2006.01) C07K 14/75 (2006.01)
Patent
CA 2531419
The invention relates to a method for obtaining cryoprecipitatable proteins, comprising a viral inactivation step by thermally treating a lyophilisate of these proteins, comprising, before rendering the proteins in the form of a lyophilisate, an initial addition step, to these proteins, of a stabilizing and solubilizing formulation containing a mixture consisting of arginine, at least one hydrophobic amino acid and of tribasic sodium citrate. The invention also relates to a concentrate consisting of at least one cryoprecipitable protein containing the stabilizing and solubilizing formulation introduced according to the method and being suited for therapeutic use.
L'invention concerne un procédé d'obtention de protéines cryoprécipitables, comprenant une étape d'inactivation virale par traitement thermique d'un lyophilisat desdites protéines, comportant, avant la mise des protéines sous la forme de lyophilisat, une étape initiale d'ajout, auxdites protéines, d'une formulation stabilisante et solubilisante comprenant un mélange d'arginine, d'au moins un acide aminé hydrophobe et de citrate trisodique. L'invention concerne également un concentré d~au moins une protéine cryoprécipitable comprenant la formulation stabilisante et solubilisante introduite selon le procédé et susceptible d'être destiné à un usage thérapeutique.
Bardat Annie
Begin Edith
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
Robic
LandOfFree
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