C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.14, 195/1.
C12N 15/70 (2006.01) C07K 14/47 (2006.01) C07K 14/58 (2006.01) C07K 14/605 (2006.01) C07K 14/785 (2006.01) C12N 9/10 (2006.01) C12N 9/64 (2006.01) C12N 15/54 (2006.01) C12N 15/62 (2006.01)
Patent
CA 1320162
METHOD FOR STABILIZING HETEROLOGOUS PROTEIN EXPRESSION AND VECTORS FOR USE THEREIN Abstract of the Invention The present invention provides a method for stabilizing heterologous protein expression in bacteria by using a 3' truncated chloramphenicol acetyltransferase (CAT) gene fused in frame with a gene encoding a heterolo- gous protein. When expressed in a bacterial host, the resulting hybrid gene produces a fusion protein in re- coverable yield. Cleavage sites separating the CAT and heterologous protein are also provided to facilitate isolation and purification of the desired heterologous protein The invention further provides bacterial vectors containing the hybrid gene fusions for expression of the fusion protein comprising the desired heterologous protein.
607908
Hilliker Sandra
White R. Tyler
Ade & Company
California Biotechnology Inc.
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