Method for stabilizing macrolide compound

Details Method for stabilizing macrolide compound Method for stabilizing macrolide compound

C - Chemistry, Metallurgy

07

D

C07D 407/06 (2006.01) C07D 313/00 (2006.01) C08B 37/16 (2006.01) C12P 17/08 (2006.01)

Patent

CA 2553573

A method of stabilizing a macrolide compound and a process for efficiently producing the compound. The method, which is for stabilizing a 12-membered cyclic macrolide compound, e.g., that represented by the formula (I), comprises causing the compound to coexist with a cyclodextrin. The process, which is for producing the macrolide compound, comprises causing a cyclodextrin to be present in a culture medium containing an actinomyces having the ability to produce the macrolide compound. (I)

Méthode de stabilisation d~un composé de macrolide et procédé de production efficace du composé. La méthode, qui concerne la stabilisation d~un composé de macrolide cyclique à 12 chaînons par exemple, tel que détaillé dans la formule (I), fait coexister le composé avec une cyclodextrine. Le procédé, qui permet de produire un composé de macrolide, introduit une cyclodextrine dans un milieu de culture contenant un actinomycète qui a la capacité de produire le composé de macrolide. (I)

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