A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/58 (2006.01) A61K 9/14 (2006.01) A61K 9/19 (2006.01) A61K 47/12 (2006.01) A61K 47/26 (2006.01)
Patent
CA 2278199
A method for elevating the stability of peptides containing the sequence -Asp- Gly- or -Asn-Gly- by preventing these sequences from changing into succinimide compounds or .beta.-transition compounds with the passage of time; and freeze- dried medicinal compositions containing hirudin, having excellent stability, and obtained by using the above method. The method comprises adding an organic acid to the solution of the above peptide to regulate the pH value of the solution to 5 to 6.5 followed by freeze-drying. As the peptide, use may be made of disulfite hirudin, hirudin variants, etc. It is also possible to add sucrose, mannitol, etc., together with the organic acid.
L'invention concerne un procédé qui permet d'augmenter la stabilité de peptides comprenant la séquence -Asp-Gly- ou -Asn-Gly- en empêchant la transformation desdites séquences, avec le temps, en composés de succinimide ou en composés de .beta.-transition; l'invention concerne également des compositions médicinales lyophilisées comprenant de l'hirudine et possédant une excellente stabilité, obtenues par le procédé en question. Le procédé consiste à ajouter un acide organique à la solution dudit peptide pour régler le pH de la solution entre 5 et 6,5, et à procéder à la lyophilisation. Parmi les peptides, on peut utiliser le bisulfite d'hirudine, des variantes de l'hirudine, etc. Outre l'acide organique, on peut également ajouter du saccharose, du mannitol, etc.
Furuya Hideyuki
Michibuchi Kose
Morita Hiroyuki
Takatsu Yukitaka
Tanigawa Makoto
Dennison Associates
Japan Energy Corporation
LandOfFree
Method for stabilizing peptides and freeze-dried medicinal... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for stabilizing peptides and freeze-dried medicinal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for stabilizing peptides and freeze-dried medicinal... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1778734