Method for stabilizing tissue plasminogen activator and a...

Details Method for stabilizing tissue plasminogen activator and a... Method for stabilizing tissue plasminogen activator and a...

C - Chemistry, Metallurgy

12

N

195/35.2

C12N 9/96 (2006.01) A61K 47/42 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1206434

ABSTRACT OF THE DISCLOSURE A method for stabilizing a tissue plasminogen activator which involves adding to an aqueous solution or powder containing a tissue plasminogen activator an effective amount of a purified gelatin is disclosed. A stable aqueous solution or powder which contains a tissue plasminogen activator and an effective amount of a purified gelatin is also disclosed. The method and composition eliminate the problem of adsorption of tissue plasminogen activatOr to various laboratory equipment, and also prevent the conversion of the single-chain tissue plasminogen activatgor into a double-chain tissue plasminogen activator.

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