Method for study, determination or evaluation

Details Method for study, determination or evaluation Method for study, determination or evaluation

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) A61K 35/00 (2006.01) A61P 25/04 (2006.01) A61P 25/20 (2006.01) G01N 27/447 (2006.01)

Patent

CA 2600093

It is intended to provide a method for studying, determining or evaluating a pharmacological effect such as an effect on fibromyalgia, an analgesic effect or an antistress effect of a test substance by administering the test substance to a SART stress-loaded animal and then subjecting the brain tissue to expression and proteome analysis. By conducting the expression and proteome analysis to examine how the test substance affects a change in protein expression occurring in the brain tissue of the SART stress-loaded animal, it is possible to search for a substance efficacious against fibromyalgia or painful diseases, an antistress agent and so on.

L'invention est prévue pour fournir un procédé destiné à étudier, mesurer ou évaluer un effet pharmacologique tel qu'un effet sur la fibromyalgie, un effet analgésique ou un effet anti-stress d'une substance d'essai en administrant la substance d'essai à un animal soumis à un stress entraîné par une altération des rythmes à la température ambiante (SART), puis en soumettant le tissu du cerveau à une analyse de l'expression et du protéome. En réalisant l~analyse de l'expression et du protéome de façon à examiner la manière dont la substance d'essai affecte un changement de l'expression de la protéine se produisant dans le tissu du cerveau de l'animal soumis à un stress SART, il est possible de rechercher une substance efficace contre la fibromyalgie ou des maladies douloureuses, un agent anti-stress, etc.

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