Method for subretinal administration of therapeutics...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2498489

Featured is a methodology for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. In particular embodiments, the therapeutic medium is disposed in a sub retinal space. Such instillation being accomplished by one of injection or implantation of the therapeutic medium sub-retinally or the sub-retinal space. In other aspects, the methodology further includes forming a limited retinal detachment so as to define the sub-retinal space as well as methods for treating an eye by sub-retinally administering a therapeutic medium.

L'invention concerne un procédé servant à administrer un agent thérapeutique au segment postérieur de l'oeil, ce qui consiste à instiller ou à placer cet agent thérapeutique sous la rétine. Dans des modes de réalisation spécifiques, cet agent thérapeutique est placé dans un espace sub-rétinien. L'instillation s'effectue par injection ou implantation de l'agent thérapeutique sous la rétine ou dans l'espace sub-rétinien. Dans d'autres aspects, ce procédé consiste, de plus, à effectuer une ablation rétinienne limitée, de manière à définir l'espace sub-rétinien.Elle concerne également des procédés servant à traiter l'oeil par administration sub-rétinienne d'un agent thérapeutique.

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