Method for suppressing coloring of adhesive preparation...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/445 (2006.01) A61K 9/70 (2006.01) A61K 47/02 (2006.01) A61K 47/22 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2671000

[PROBLEMS] To prevent the coloration in a donepezil-containing skin adhesive preparation to achieve the appearance having a natural color, or the like. [MEANS FOR SOLVING PROBLEMS] Disclosed is a method for preventing the coloration in a skin adhesive preparation comprising a substrate and an adhesive layer, wherein the adhesive layer comprises an adhesive agent and donepezil. The method is characterized by adding ascorbic acid or a metal salt or ester thereof and a metabisulfite metal salt to the adhesive layer. Preferably, the method comprises the steps of: providing a preparation product comprising the adhesive agent, donepezil, ascorbic acid or a metal salt or ester thereof and a metabisulfite metal salt; and applying the preparation product onto the surface of the substrate to form the adhesive layer.

[Problèmes] Prévenir la coloration dans une préparation d'adhésif cutané contenant du donépézil afin d'obtenir une apparence de couleur naturelle, ou analogue. [Solutions] Un procédé destiné à prévenir la coloration dans une préparation d'adhésif cutané comprenant un substrat et une couche adhésive, la couche adhésive contenant un agent adhésif et du donépézil. Ce procédé est caractérisé en ce qu'il ajoute de l'acide ascorbique ou un sel ou un ester métallique de celui-ci et un sel métallique métabisulfite à la couche adhésive. De préférence, ce procédé comprend les étapes consistant: à fournir un produit de réparation contenant l'agent adhésif, le donépézil, l'acide ascorbique ou un sel ou un ester métallique de celui-ci et un sel métallique métabisulfite; et à appliquer le produit de préparation sur la surface du substrat afin de former la couche adhésive.

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