C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01)
Patent
CA 2297124
The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo--pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3--dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.
Ces procédés de synthèse de dérivés halopyridyl-azacyclopentane, actifs sur le plan optique, et d'intermédiaires de ceux-ci, consistent à convertir un dérivé d'ester d'acétone-dicarboxylique actif sur le plan optique, pour obtenir un ester d'allène-1,3-dicarboxylique actif sur le plan optique, puis à convertir ce dérivé pour obtenir un dérivé objet de l'invention, au moyen d'un dérivé de 7-azabicyclo[2.2.1]heptane.
Fujiwara Toshio
Ichihashi Shogo
Nakamura Daisaku
Node Manabu
Marks & Clerk
Nihon Medi-Physics Co. Ltd.
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