Method for synthesis of phospholipids-peg-biomolecule...

Details Method for synthesis of phospholipids-peg-biomolecule... Method for synthesis of phospholipids-peg-biomolecule...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2551437

The present invention relates to methodology of manufacturing phospholipids- PEG- biomolecule conjugates suitable for use as a component of diagnostic or therapeutic liposomes/micelles in targeted diagnostics or therapy and concerns specifically a simple method of synthesis, purification and analysis of phospholipid biomolecule, e.g. peptide, conjugates. The invention thus provides micellar peptides, which can be used for improving targeting of liposomes/micelles to tumour cells, for enhancing the uptake of liposomes by tumour cells, and for selected liposomal delivery of chemotherapeutic agents into tumour cells.

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