Method for synthesising and immobilizing nucleic acids on a...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) B01J 19/00 (2006.01) C07B 61/00 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2397606

The invention concerns the use, for synthesising and immobilising nucleic acids, of a solid support modified by an organised self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesising and immobilising nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.

La présente invention se rapporte à l'utilisation, pour la synthèse ou l'immobilisation d'acides nucléiques, d'un support solide modifié par une monocouche autoassemblée organisée d'un ou de plusieurs composés organosiliciés. La présente invention se rapporte également à des procédés de synthèse et d'immobilisation d'acides nucléiques sur un tel support solide silanisé, ainsi qu'à des puces à ADN obtenues par ces procédés.

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