Method for synthesizing a peptide containing a non-peptide bond

Details Method for synthesizing a peptide containing a non-peptide bond Method for synthesizing a peptide containing a non-peptide bond

C - Chemistry, Metallurgy

07

K

530/7.2

C07K 1/10 (2006.01) C07K 7/00 (2006.01) C07K 7/02 (2006.01) C07K 7/23 (2006.01)

Patent

CA 1307623

Abstract This invention features a method for the solid phase synthesis of non-peptide bonds (CH2-NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH3. This invention also features somatostatin analogs with non-peptide bonds. This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing .alpha.-N-R and side group N-R analogs of peptides, where R is an alkyl or aryl group, by reacting a carbonyl- containing compound and an amino acid in the presence of NaCNBH3.

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