Method for synthesizing vitamin d analogs

Details Method for synthesizing vitamin d analogs Method for synthesizing vitamin d analogs

C - Chemistry, Metallurgy

07

F

C07F 9/53 (2006.01) C07C 401/00 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2744591

Processes for preparing vitamin D2 derivatives and intermediates to vitamin D2 derivatives are disclosed. An improved photolysis process for the preparation of cis intermediate (I) from the trans starting material (II) are disclosed. Also disclosed is an improved process for the formation of a trans double bond at C22-C23 of the vitamin D2 derivative, which provides high selectivity of the desired trans double bond of compound (III) over the undesired cis double bond of compound (IIIA).

La présente invention concerne des procédés pour préparer des dérivés de vitamine D2 et des intermédiaires de dérivés de vitamine D2 dérivés. La présente invention concerne en outre un procédé de photolyse amélioré pour la préparation dintermédiaire cis (I) à partir du matériau de départ trans (II). La présente invention concerne en outre un procédé amélioré pour la formation dune double liaison trans à C22-C23 du dérivé de vitamine D2, qui présente une sélectivité élevée pour la double liaison trans souhaitée du composé (III) par rapport à la double liaison cis indésirable du composé (IIIA).

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