C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/02 (2006.01)
Patent
CA 2544950
A method for the catalytic conversion of codeine, morphine or analogs thereof into hydrocodone, hydromorphone or analogs thereof utilizing a transition metal catalyst of the formula [M(PR3R4R5)nXm]p; wherein R1 is H, alkyl, aryl or acyl; M is a Group VIII transition metal; R3, R4 and R5 are selected from the group consisting of alkyl, aryl, alkoxyl, phenoxyl and combinations thereof; X is a halide or an anion; n is 1, 2, 3 or 4; m is 1 or 2; and p is at least 1.
Un procédé pour conversion catalytique de codéine, morphine ou analogues de celles-ci en hydrocodone, hydromorphone ou analogues de celles-ci en utilisant un catalyseur métallique de transition de formule [M(PR?3¿R?4¿R?5¿)¿n?X¿m?]¿p?; dans laquelle R?1 ¿est un H, un alkyle, un aryle ou un acyle; M est un métal de transition du groupe VII; R?3¿, R?4¿ et R?5¿ sont sélectionnés à partir du groupe consistant en alkyle, aryle, alkoxyle, phénoxyle et combinaisons de ceux-ci; X est un halogénure ou un anion; n est 1, 2, 3 ou 4; m est 1 ou 2; et p est au moins égal à 1.
Wang Peter Xianqi
White Carl Ray
Mallinckrodt Inc.
Osler Hoskin & Harcourt Llp
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