Method for the covalent attachment of polysaccharides to...

Details Method for the covalent attachment of polysaccharides to... Method for the covalent attachment of polysaccharides to...

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/34 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2305620

Disclosed and claimed are a method for the covalent attachment of poly- and oligosaccharides to protein molecules via hydrogen peroxide depolymerization of the polysaccharide units, followed by attachment of the depolymerized polysaccharide chain to the amino acid groups of a protein of interest through a linker molecule, and products therefrom, and methods for using the products.

L'invention concerne un procédé consistant à lier par covalence des polysaccharides et des oligosaccharides à des molécules protéiniques, grâce à une dépolymérisation à l'eau oxygénée des motifs polysaccharides. Ce procédé consiste ensuite à fixer la chaîne de polysaccharides dépolymérisés aux groupes d'acides aminés d'une protéine d'intérêt, par l'intermédiaire d'une molécule de liaison. Cette invention concerne également les produits obtenus grâce à ce procédé, et les procédés d'utilisation de ces produits.

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