Method for the detection of multiple drug resistant tumor...

Details Method for the detection of multiple drug resistant tumor... Method for the detection of multiple drug resistant tumor...

C - Chemistry, Metallurgy

07

C

167/47, 260/599.

C07C 247/16 (2006.01) C07D 493/10 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2000082

Abstract of the Disclosure A method for the detection of multiple drug resistant tumor cells is described which comprises the incubation of a sample of mammalian tumor cellular material with an effective binding amount of a labelled verapamil derivative to form an complex with any P-gp that is present, and then determining the amount of P-gp present by quantifying the amount of labelled verapamil derivative bound in the complex. Photoaffinity, radiolabelled and chemoaffinity derivatives of verapamil and the syntheses of such derivatives are described, as are a method of treatment for multiple drug resistant tumors and a diagnostic kit.

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