C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/527 (2006.01)
Patent
CA 2382488
The invention relates to a method for the detection of a soluble guanylate cyclase, whose haem iron is present in a trivalent oxidation state and a method for detecting chemical substances which stimulate the activity of soluble guanylate cyclase when said haem iron present in soluble guanylate cyclase is at least in part trivalently oxidized. Said invention also relates to a diagnostic agent for detecting a soluble guanylate cyclase containing trivalent haem iron.
L'invention concerne un procédé pour la mise en évidence d'une guanylate-cyclase soluble dont le fer hémique est présent au degré d'oxydation trivalent, un procédé pour la détection de substances chimiques stimulant l'activité d'une guanylate-cyclase soluble lorsque le fer hémique d'au moins une partie de cette guanylate-cyclase soluble a subi une oxydation trivalente, ainsi qu'un agent diagnostique pour la mise en évidence d'une guanylate-cyclase à fer hémique trivalent.
Mulsch Alexander
Schindler Peter
Schindler Ursula
Strobel Hartmut
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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