C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12Q 1/02 (2006.01) C12Q 1/06 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2478220
The present invention relates to a method for detecting a prion in a sample comprising providing a population of cells which are susceptible to prion infection, contacting the population of cells with the cells with the sample, incubating the cells on a growth substrate, assaying for prion colony formation wherein presence of prion colonies indicates presence of prions in the sample. The invention further relates to methods for quantifying the prions, and to cell lines sensitive to prion infection.
L'invention porte sur un procédé de détection de prions dans un échantillon consistant: à obtenir une population de cellules susceptibles d'être infectées par des prions; à mettre en contact la population de prions avec l'échantillon; à incuber les cellules sur un substrat de croissance; et à détecter la présence possible d'une colonie de prions, dont l'existence révèle celle de prions dans l'échantillon. L'invention porte également des méthodes de quantification des prions, et sur des lignées de cellules susceptibles d'être infectées par des prions.
Enari Masato
Flechsig Eckhard
Kloehn Peter
Stoltze Lars
Weissmann Charles
D-Gen Limited
Gowling Lafleur Henderson Llp
Medical Research Council
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