Method for the determination of anti-p. falciparum...

Details Method for the determination of anti-p. falciparum... Method for the determination of anti-p. falciparum...

G - Physics

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G01N 33/535 (2006.01) A61K 39/015 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) C07K 7/10 (1990.01)

Patent

CA 1299101

CASE 2439 "METHOD FOR THE DETERMINATION OF ANTI-P. FALCIPARUM SPOROZOITE ANTIBODIES IN HUMAN BLOOD" Abstract An immunoenzimatic method is disclosed for the detection and the measurement of anti-P. falciparum sporozoite antibodies in human blood and/or in its derivatives, which operates with a synthetic antigen- enzyme conjugate capable of forming with the antisporozoite antibodies a stable antibody-synthetic antigen-enzyme complex, and one or more proteins adsorbed and/or covalently linked to a solid support, which eagerly bind the antisporozoite antibody of said complex. The method, thanks to its simpleness, specificity and rapidity, is particularly useful in epidemiologic investigations into malaria and into the efficacy of an antimalarial vaccine.

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