Method for the dissociation of the extracellular haemoglobin...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/805 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2542478

The invention relates to a method of dissociating the extracellular haemoglobin molecule of annelids, e.g. Arenicola marina, which can be used to obtain the protein chains forming said molecule. The inventive method is characterised in that it comprises a step consisting in bringing an extracellular haemoglobin sample from annelids, e.g. Arenicola marina, into contact with at least one dissociating agent, e.g. a mixture containing dithiothreitol (DTT) or tris(2-carboxyethyl)phosphine (TCEP) hydrochloride or beta-mercaptoethanol and a dissociation buffer for a sufficient length of time in order to separate the protein chains from one another.

La présente invention concerne un procédé de dissociation de la molécule d'hémoglobine extracellulaire d'Annélides, notamment d'Arenicola marina, permettant l'obtention des chaînes protéiques constituant ladite molécule, ledit procédé étant caractérisé en ce qu'il comprend une étape de mise en présence d'un échantillon d'hémoglobine extracellulaire d'Annélides, notamment d'Arenicola marina avec au moins un agent dissociant, notamment un mélange constitué de dithiothréitol (DTT) ou de chlorhydrate de tris(2- carboxyéthyl)phosphine (TCEP) ou de bêta-mercaptoéthanol et d'un tampon de dissociation, pendant un temps suffisant pour séparer les chaînes protéiques les unes des autres.

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