C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/22 (2006.01)
Patent
CA 2452263
The invention relates to a method for the enantioselective reduction of a prochiral aromatic ketone comprising at least one trifluoromethyl group on the aromatic cycle. The inventive method can be used to gain access primarily to an alcohol with configuration (R). Said method is characterised in that the reduction of the prochiral aromatic ketone comprising at least one trifluoromethyl group on the aromatic cycle is carried out in the presence of the Lactobacillus enzyme.
La présente invention a pour objet un procédé de réduction énantiosélectif d'une cétone aromatique prochirale comprenant au moins un groupe trifluorométhyle sur le cycle aromatique.Le procédé de l'invention qui permet d'accéder majoritairement ô un alcool de configuration (R) est caractérisé par le fait que la réduction de la cétone aromatique prochirale comprenant au moins un groupe trifluorométhyle sur le cycle aromatique est effectuée en présence de l'enzyme provenant de Lactobacillus.
Bensoussan Claude
Gelo-Pujic Mirjana
Rhodia Chimie
Robic
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