Method for the enzymatic synthesis of alpha-sialylated...

Details Method for the enzymatic synthesis of alpha-sialylated... Method for the enzymatic synthesis of alpha-sialylated...

C - Chemistry, Metallurgy

12

P

C12P 19/26 (2006.01) A61K 39/385 (2006.01) C07H 3/06 (2006.01) C07H 15/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2110386

Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides: Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to an oligosaccharide glycoside. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the sialyltransferase employed.

Dans les méthodes décrites, la sialyltransférase est activée pour transférer à un glycoside d'oligosaccharide un analogue d'acide sialique, utilisé en tant que son dérivé nucléotidique de CMP. L'analogue d'acide sialique et l'oligosaccharide utilisés dans ladite méthode sont choisis de manière à être compatibles avec la sialyltransférase utilisée.

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