Method for the fractionation of knotwood extract and use of...

C - Chemistry – Metallurgy – 07 – D

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C07D 311/26 (2006.01)

Patent

CA 2728934

The invention relates to a method for the fractionation of knotwood extract, which has been obtained by extraction of knotwood with a hydrophilic solvent. The hydrophilic extract is extracted with a lipophilic solvent to remove lipophilic impuri-ties. The invention also relates to the use of a liquid-liquid extraction for the purification of hydrophilic knotwood extract. The present process provides a purified knotwood extract, which contains more than 90 % lignans, flavonoids and stilbenes and less than 10 % impurities selected from resin acids, fatty acids, sterols, juvabiones, triglycerides and combinations thereof.

L'invention concerne un procédé de fractionnement d'extrait de bois noueux, qui a été obtenu par extraction de bois noueux avec un solvant hydrophile. L'extrait hydrophile est extrait avec un solvant lipophile pour éliminer les impuretés lipophiles. L'invention concerne également l'utilisation d'une extraction liquide-liquide pour la purification d'extrait de bois noueux hydrophile. Le présent procédé donne un extrait de bois noueux purifié, qui contient plus de 90 % de lignanes, de flavonoïdes et de stilbènes, et moins de 10 % d'impuretés choisies parmi des acides résiniques, des acides gras, des stérols, des juvabiones, des triglycérides et leurs combinaisons.

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