C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2549948
The invention relates to methods and compounds which can modulate the reverse transport of cholesterol in a mammal and to screening methods enabling the selection, identification and/or characterization of compounds which can modulate the reverse transport of cholesterol. The invention also relates to cells, vectors and genetic constructions which can be used to implement said methods, in addition to pharmaceutical compounds used for the treatment of atherosclerosis. The methods of the invention are based on the use of elements responding to LRH-1 derivative response element derived from the apo AI gene promoter.
La présente invention concerne des méthodes et composés susceptibles de moduler le transport inverse du cholestérol chez un mammifère ainsi que des méthodes de criblage permettant de sélectionner, d'identifier et/ou de caractériser des composés capables de moduler le transport inverse du cholestérol. Elle concerne également des cellules, vecteurs et constructions génétiques utilisables pour la mise en oeuvre de ces méthodes, ainsi que des compositions pharmaceutiques destinées au traitement de l'athérosclérose. Les méthodes de l'invention sont basées sur l'utilisation d'éléments de réponse à LRH-1 dérivés du promoteur du gène apo AI.
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Robic
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