C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) A61K 38/00 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2542104
The present invention relates to a method for identifying peptides involved in immunogenicity comprising the steps of a) providing cells expressing antigen presenting receptors (APR) in a number providing 0.1 to 5 µg molecules, b) contacting the cells from (a) with a source of immunogenic peptides, c) isolating APR molecule-immunogenic peptide complexes from the cells, d) eluting the associated peptides from the APR molecules, e) identifying the immunogenic peptides, f) verifying the identified immunogenic peptides as epitopes.
La présente invention porte sur une méthode qui permet d'obtenir des peptides jouant un rôle immunogène comprenant les étapes suivantes : a) fournir des cellules exprimant une quantité de récepteurs présentant des antigènes (RPA) variant entre 0,1 et 5 microgrammes, b) mettre en contact les cellules en a) avec une source de peptides immunogènes, c) isoler les complexes formés de RPA et de peptides immunogènes à partir des cellules, d) dissocier les peptides des RPA, e) identifier les peptides immunogènes, f) vérifier que les peptides immunogènes identifiés ont un épitope.
Kropshofer Harald
Vogt Anne
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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