G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 5/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2491345
The present invention relates generally to a method of identifying ligands that modulate protein-protein interactions. More particularly, the present invention relates to methods of determining agonists or antagonists of a co- regulator dependent target molecule based on the ability to modify the stability of the target molecule.
La présente invention porte, d'une manière générale, sur un procédé d'identification de ligands qui modulent les interactions protéine-protéine. Cette invention porte en particulier sur des procédés permettant de déterminer des agonistes ou antagonistes d'une molécule cible dépendant d'un co-régulateur sur la base de l'aptitude à modifier la stabilité de la molécule cible.
Askari Hossein
Bone Roger F.
Rentzeperis Dionisios
Salemme Francis R.
Springer Barry A.
3-Dimensional Pharmaceuticals Inc.
Johnson & Johnson Pharmaceutical Research & Development L.l.c.
Mbm Intellectual Property Law Llp
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