Method for the identification of ligands

Details Method for the identification of ligands Method for the identification of ligands

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2491468

The present invention relates generally to a method of identifying ligands that modulate protein-protein interactions. More particularly, the present invention relates to methods of determining agonists or antagonists of a co- regulator dependent target molecule based on the ability to modify the stability of the target molecule in a tissue~-selective manner.

La pr~sente invention concerne g~n~ralement une m~thode d'identification de ligands, qui module des interactions prot~ine-prot~ine. Plus particuli­rement, l'invention concerne des m~thodes pour d~terminer des agonistes et des antagonistes d'une mol~cule cible d~pendante d'un co-r~gulateur, ces m~thodes ~tant bas~es sur l'aptitide ~ modifier la stabilit~ de la mol~cule cible d'une mani­re s~lective pour le tissu.

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