Method for the identification of macromolecule targets of...

G - Physics – 01 – N

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G01N 33/53 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2634821

There is provided a method for the identification of macromolecule targets of analytes such as drugs in biological samples comprising complex mixtures of macromolecules. A biological sample is contacted with one or more analyte and the mixture is resolved such that the analyte and its target are co-eluted and analyzed to identify analyte-target complexes.

L'invention concerne un procédé d'identification de cibles de macromolécules de substances à analyser telles que des médicaments dans des échantillons biologiques comprenant des mélanges complexes de macromolécules. Un échantillon biologique est mis en contact avec une ou plusieurs substances à analyser et le mélange est résolu de telle sorte que la substance à analyser et sa cible soient co-éluées et analysées pour identifier des complexes substances à analyser-cibles.

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