Method for the in vitro diagnosis of stroke

Details Method for the in vitro diagnosis of stroke Method for the in vitro diagnosis of stroke

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2751090

The present invention relates to a method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, comprising the following steps: (a) measuring the level of proBNP(1 -108), or of fragments of proBNP(1-108) comprising a RAPRSP sequence (SEQ ID NO: 1), in a biological sample of the individual; (b) measuring the level of nucleoside diphosphate kinase A (NDKA) in a biological sample of the individual; (c) comparing the level of proBNP(1 -108), or of fragments of proBNP(1 -108), and the level of NDKA, with one or several cut-off values; (d) determining therefrom whether a stroke or a TIA has occurred in the individual.

La présente invention concerne un procédé pour le diagnostic in vitro d'un accident vasculaire cérébral et d'une attaque ischémique transitoire (TIA), chez un individu, qui comporte les étapes suivantes : (a) la mesure du taux de proBNP(1-108), ou de fragments de proBNP(1-108) comportant une séquence RAPRSP (SEQ ID NO: 1), dans un échantillon biologique de l'individu ; (b) la mesure du taux de nucléoside diphosphate kinase A (NDKA) dans un échantillon biologique de l'individu ; (c) la comparaison du taux de proBNP(1-108), ou de fragments de proBNP(1-108), et du taux de NDKA, avec une ou plusieurs valeurs de seuil ; (d) la détermination, à partir de ceci, si un accident vasculaire cérébral ou un TIA s'est produit chez l'individu.

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