Method for the inhibition of aldh-i useful in the treatment...

Details Method for the inhibition of aldh-i useful in the treatment... Method for the inhibition of aldh-i useful in the treatment...

C - Chemistry, Metallurgy

07

D

C07D 311/36 (2006.01) A61K 31/35 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2112703

Method for inhibiting aldehyde dehydrogenase activity using daidzin and/or daidzin analog and/or daidzin or daidzin analog in combination with a factor or factors which increase the bioavaiiability of the daidzin or daidzin analog, as ALDH-I inhibitory compounds or compositions. Such inhibitory compounds or compositions are useful as pharmaceutical compositions in methods for the treatment of alcohol dependence (i.e., alcoholism) or alcohol abuse, for alcohol sensitization, for extinguishing an alcohol-drinking response, for suppressing an urge for alcohol, for inducing alcohol intolerance, for preventing alcoholism in an individual with or without a susceptibility or predisposition to alcoholism or alcohol abuse, and for limiting alcohol consumption in an individual whether or not genetically predisposed.

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