Method for the isolation and purification of taxane derivatives

Details Method for the isolation and purification of taxane derivatives Method for the isolation and purification of taxane derivatives

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07C 69/00 (2006.01) C07C 69/78 (2006.01) C07H 15/26 (2006.01)

Patent

CA 2094910

2094910 9207842 PCTABS00013 An improved method for isolating certain clinically important taxane derivatives from the crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent; causing the taxane derivatives to be adsorbed on the adsorbent; and recovering the taxane derivatives from the adsorbent by elution with an eluant. The taxane derivatives thus isolated in pure form are taxol, taxol-7-xyloside, 10-deacetyltaxol, 10-deacetyltaxol-7-xyloside, cephalomannine, cephalomannine-7-xyloside, 10-deactylcephalomannine-7-xyloside, baccatin III, 10-deacetylbaccatin III, baccatin VI, and brevitaxane A.

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