Method for the manufacture of benzothiazepine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 281/02 (2006.01) C07D 281/10 (2006.01)

Patent

CA 2150766

A process for the manufacture of Diltiazem of the structural formula (see fig. I) or deacetyl-Diltiazem of the structural formula (see fig. II) which comprises the use of methyl isobutyl ketone (MIBK) as solvent and sodium hydroxide (NaOH) as base in water.

Méthode pour la production de diltiazem de formule structurelle (voir fig. I) ou de désacétyldiltiazem de formule structurelle (voir fig. II), faisant appel à la méthylisobutylcétone comme solvant et à l'hydroxyde de sodium ((NaOH) comme base dans l'eau.

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