C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/04 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 35/12 (2006.01) A61K 35/39 (2006.01) A61L 27/38 (2006.01) B01J 13/04 (2006.01)
Patent
CA 2223417
The present invention provides methods and a device for producing minimal volume capsules containing viable cells or cellular aggregates. The methods and device use a two-phase aqueous emulsion system to form a dispersion of liquid capsule-forming materials in a continuous liquid phase to which is added a suspension of biological material. Alternatively, the biological material can be added to one or the other of the liquid phases. The composition of this emulsion is adjusted to promote the thermodynamically- driven process for particle engulfment by the dispersed droplets of liquid capsule-forming materials. Subsequently, the droplets engulf the biological material to form a liquid film surrounding the tissue and are converted to solid form, resulting in encapsulation of the biological material in minimum volume capsules.
Cette invention porte sur des procédés de production de capsules d'un volume minimal contenant des cellules viables ou des agrégats cellulaires. Les procédés et le dispositif correspondant utilisent un système d'émulsion aqueuse comportant deux phases pour disperser les substances liquides constituantes de la capsule dans une phase liquide continue à laquelle on ajoute une suspension de substance biologique. En variante, il est possible d'adjoindre la substance biologique dans l'une ou l'autre des phases liquides. La composition de cette émulsion est adaptée pour faciliter le processus thermodynamique d'enveloppement par les gouttelettes dispersées des substances liquides constituantes de la capsule. Par la suite, les gouttelettes enveloppent la substance biologique pour constituer un film liquide entourant le tissu et passent à l'état solide, ce qui débouche sur une encapsulation de la substance biologique dans des capsules d'un volume minimal.
Lamberti Francis
Neocrin Company
Smart & Biggar
LandOfFree
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