Method for the manufacture of the derivatives of propionic acid

Details Method for the manufacture of the derivatives of propionic acid Method for the manufacture of the derivatives of propionic acid

C - Chemistry, Metallurgy

07

D

C07D 303/48 (2006.01) C07B 57/00 (2006.01) C07D 285/10 (2006.01) C07D 301/32 (2006.01)

Patent

CA 2096316

A method for the manufacture of optically active derivatives of epoxypropionic acid from racemic mixtures comprising, that a) the racemic mixture is dissolved in carbon dioxide and the obtained solution is conducted through a chromatographic column and b) the desired optical isomer of epoxypropionic acid is separated from the eluent. In this manner optically active derivatives of epoxypropionic acid useful in the manufacture of optically pure isomers of drugs can be obtained.

Méthode de fabrication de dérivés d'acide époxypropionique optiquement actifs à partir de mélanges racémiques suivant laquelle a) le mélange racémique est dissous dans le dioxyde de carbone et la solution ainsi obtenue est passée dans une colonne de chromatographie et b) l'isomère optique de l'acide époxypropionique recherché est séparé de l'éluent. On peut obtenir de cette manière des dérivés de l'acide époxypropionique optiquement actifs utiles pour la fabrication d'isomères optiquement purs de médicaments.

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